Tourism, which has become one of the world's most important industries, relies on natural and cultural values as its fundamental inputs as a sector that drives economic development and creates employment. Cultural values play a significant role in the formation of tourism at local, national, and international levels. Based on the concept of cultural routes, which are a synthesis of nature and culture, the main objective of this project, which focuses on the TRB1 region (Malatya, Elazığ, Bingöl, Tunceli), is to promote the region's natural and cultural values on an international, national, and regional scale and to strengthen its competitiveness and sustainability by enhancing its tourism infrastructure. In the province of Malatya specifically, the evaluation of natural and cultural values within the scope of tourism is an effective tool for the integration of conservation and development. The routes that will be created among tourism types and activities and the main destination networks of these routes will make significant contributions to the development of this integration..